Need some advice

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I am wondering how to best go about creating a template(s) for the attached image. The right side text and images are _nearly_ identical. The left side menu can change depending on the section being viewed - as can the content in the middle. In the top two images there is a slideshow, and in the bottom there is content that can be changed via the tabs at the top...
I'm pretty new to C5 and not quite sure how to go about this. I assume this can be handled with one template and different blocks on the page... just hoping someone can explain a little how they would do it.

Thanks

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