File Manager problems

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I have one Concrete5 site on my server that works fine (running 5.3.2). I had this problem previously when I went to put a second install on the server, and now it's happening with 5.3.3. Now, this isn't a file copy problem as I uploaded the 5.3.3 zip file to my server, expanded it there, and then ran the install from a browser window.

But, the problem is repeating itself. I'm getting a 500 error if I try to access the file manager. I even deleted the directory, re-expanded the zip file, and re-installed. Same result. Does anyone have any ideas why this is happening?