Anything is possible, but it depends on how comfortable you are with PHP coding.
If you don't want users to upload music files it makes it a lot easier -- if you are the only one putting music there you could use one of the MP3 player blocks in the marketplace. Just design the theme like you would any other Concrete5 theme, and use the MP3 player block to put music files on the page. Or you could create separate pages for each genre, put music players on those pages, then have a bunch of page list blocks on the home page that pull the most recent 5 or 10 mp3 blocks from those genre pages. I wrote a tutorial on how to do something like this for a blog:
http://c5cookbook.com/recipes/make_a_blog...
See the "Real Content Excerpts" section. It's pretty lengthy. If you're already an experienced PHP coder it won't be too hard, but if you're new to PHP it might be a bit of a stretch.

Hope that helps.

-Jordan

hey, i am mainly after a layout like alonetone.com now

Just create a theme as you normally would for concrete5 (seehttp://www.concrete5.org/documentation/how-tos/make-a-theme/... for instructions),
but instead of using a template, you just create your own html/css files to use as a template. Make the html/css look the way you want it to, and then follow the instructions I linked to above.

If you don't know how to design web pages using html/css, then you will need to learn that first (there are millions of tutorials on the internet for this -- just google it).

Good luck!